Granulation and Dry-pressing of Al2O3 Fine Powder.

1 Powder Compaction by Dry Pressing

Moisture- Activated Dry Granulation

In the pharmaceutical industry, the three most common granulation processes for solid dosage form production are wet granulation, dry granulation (roller compaction) and direct blending. Yet, despite being well-established techniques, each has its drawbacks. Moisture-activated dry granulation (MADG) was developed in response to the difficulties experienced with wet granulation, in terms of endp...

Assessing dry powder inhalers

To enable what would otherwise be impractical, invasive and potentially dangerous testing, and to remove the huge variation and costs associated with human subjects, it is common practice to test inhalation devices and formulations using in vitro test apparatus. Industry standard test conditions and relevant parameters have been devised and published by the regulatory authorities and within the...

Dry powder inhaler formulation.

A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...

Deposition and fine particle production during dynamic flow in a dry powder inhaler: a CFD approach.

In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic et al. (2013). The model integrates CFD simulations for dynamic flow, an Eulerian-fluid/Lagrangi...